4-[（1e，3s，5z，8r/s，10s）-3,11-双[叔丁基（二甲基）硅烷基]氧基-2,6,10-三甲基-8-（苯磺酰）十一烷-1,5-二烯基]-2-甲基-1,3-噻唑
2019-04-01
产品详情
- 产地 加拿大
- Cas：308357-81-5
- 价格：99
- 产品名称4-[（1e，3s，5z，8r/s，10s）-3,11-双[叔丁基（二甲基）硅烷基]氧基-2,6,10-三甲基-8-（苯磺酰）十一烷-1,5-二烯基]-2-甲基-1,3-噻唑
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- 简介
货号：02-415850
中文名称：4-[（1e，3s，5z，8r/s，10s）-3,11-双[叔丁基（二甲基）硅烷基]氧基-2,6,10-三甲基-8-（苯磺酰）十一烷-1,5-二烯基]-2-甲基-1,3-噻唑
英文名称：4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazole
CAS号：308357-81-5
重量：500mg
重量：5g
分子式：C36H61NO4S2Si2
别名：4-[(1E,3S,5Z,10S)-3,11-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,6,10-trimethyl-8-(phenylsulfonyl)-1,5-undecadien-1-yl]-2-methyl-thiazole;
应用介绍：An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.
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