（3S，6R，7S，12Z，15S，16E）-3,7-双[叔丁基（二甲基）硅烷基]氧基-15-羟基-4,4,6,8,12,16-六甲基-17-（2-甲基-1,3-噻唑-4-基）-5-氧代庚-12,16-二烯酸
2019-04-01
产品详情
- 产地 加拿大
- Cas：193146-26-8
- 价格：99
- 产品名称（3S，6R，7S，12Z，15S，16E）-3,7-双[叔丁基（二甲基）硅烷基]氧基-15-羟基-4,4,6,8,12,16-六甲基-17-（2-甲基-1,3-噻唑-4-基）-5-氧代庚-12,16-二烯酸
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- 简介
货号：02-415725
中文名称：（3S，6R，7S，12Z，15S，16E）-3,7-双[叔丁基（二甲基）硅烷基]氧基-15-羟基-4,4,6,8,12,16-六甲基-17-（2-甲基-1,3-噻唑-4-基）-5-氧代庚-12,16-二烯酸
英文名称：(4S,7R,8S,9S,13Z,16S)-4,8-Bis-{[tert-butyl(dimethyl)silyl]oxy}-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxocyclohexadec-13-ene-2,6-dione
CAS号：193146-26-8
重量：0.1mg
重量：1mg
分子式：C39H71NO6SSi2
别名：[3S-(3R*,6S*,7R*,8R*,12Z,15R*,16E)]-3,7-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-4-thiazolyl)-5-oxo-12,16-heptadecadienoic Acid;
应用介绍：An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.
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